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Sulfuric ester hydrolases

Some sulfatases (sulfuric ester hydrolases, EC 3.1.6) play a pharmacological role in the hydrolysis of sulfuric acid ester metabolites and the few such esters that are used as prodrugs. Arylsulfatase (sulfatase, arylsulfohydrolase,... [Pg.56]

A number of enzymes known as sulfuric ester hydrolases (EC 3.1.6) are able to hydrolyze sulfuric acid esters. They comprise arylsulfatase (sulfatase, EC 3.1.6.1), steryl-sulfatase (steroid sulfatase, steryl-sulfate sulfohydrolase, arylsulfatase C, EC 3.1.6.2), choline-sulfatase (choline-sulfate sulfohydrolase, EC 3.1.6.6), and monomethyl-sulfatase (EC 3.1.6.16). Whereas mono-methyl-sulfatase is highly specific and does not act on higher homologues, arylsulfatase has a broad substrate specificity and is of particular significance in the hydrolysis of sulfate conjugates of phenols, be they endogenous compounds, drugs, or their metabolites [167-169],... [Pg.594]

Esterases a large group of hydrolases acting on ester bonds R CXTOR -f HjO - R COOH-r R OH. The acid may be a carboxylic acid, phosphoric or sulfuric acid. The ester may be an alcoholic or a thiol ester. [Pg.203]

See other pages where Sulfuric ester hydrolases is mentioned: [Pg.43]    [Pg.239]    [Pg.571]    [Pg.659]    [Pg.659]    [Pg.7]    [Pg.863]    [Pg.43]    [Pg.239]    [Pg.571]    [Pg.659]    [Pg.659]    [Pg.7]    [Pg.863]    [Pg.145]    [Pg.27]    [Pg.383]    [Pg.36]   


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Sulfuric esters

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