Thiopental Sulfafurazole

The anaesthetic effects of thiopental are increased but shortened by sulfafurazole. Phenobarbital appears not to affect the pharmacokinetics of sulfafurazole or sulfisomidine. 

A study in 48 patients found that intravenous sulfafurazole 40 mg/kg re-dueed the required anaesthetie dosage of thiopental by 36%, but the duration ofaetion was shortened. This interaction has also been observed in animal experiments. A study in children showed that phenobarbital did not affect the pharmacokinetics of sulfafurazole or sulfisomidine. ... 

It has been suggested that sulfafurazole successfully competes with thiopental for plasma protein binding sites, the result being that more free and active barbiturate molecules remain in circulation to exert their anaesthetic effects and therefore smaller doses are required. 

The evidence for an interaction between sulfafurazole and thiopental is limited, but it appears to be strong. Less thiopental than usual may be required to achieve adequate anaesthesia, but since the awakening time is shortened repeated doses may be needed. Phenobarbital does not appear to affect the pharmacokinetics of the sulfonamides. 

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See also in sourсe #XX -- [ ]

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