Sulfadimidine disposition

Figure 4. Disposition of sulfadimidine (SDM), its 6-methylhydro-xy (CH OH), 5-hydroxy (SOH) and N -acetyl (N ) metabolites in milk of a dairy cow following intravenous administration of 200 mg SDM/kg.

Figure 5. Disposition of sulfadimidine in urine, bile, plasma and tissues of calves following intravenous administration of 65 mg/kg intravenously.

Laying-hens eliminate sulfadimidine rapidly by metabolic pathways including hydroxylation and acetylation. Following intravenous SDM administration, a biphasic elimination-time curve was noticed 10.2 + 3.3 H). Figure 8 shows the plasma disposition of SDM and its metabolites following an oral SDM bolus administration once daily of 100 mg/kg to a chicken. The percentage of N -SDM in plasma is the highest (Table I). Within 3 days of termination of the SDM therapy, plasma concentrations of SDM and its metabolites falls rapidly below the detection limit of the HPLC method (0.02 /ig/ml). 

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