Sugars 1-acylamido derivatives

TLC on silica gel G has been useful particularly in the organic synthesis of amino sugars for the characterization of derivatives which are not readily detected on paper. It has found application in the synthesis of 4-acetamido-4-deoxy-D- reofuranose [41], 2,6-diamino-2, 6-dideoxy-D-mannose dihydrochloride [42], 2,3-epimino-hexopyranosides [43], 2-amino-2,6-dideoxy-D-galactose [44], the l-O-acyl-2-acylamido-... 

There is one report (Benson, 1975) in which the proposed mechanism of the reaction of a sugar derivative (Morgan-Elson assay for 2-acylamido-2-deoxy-D-hexose sugars) has been tested using the sugar derivative bound to a polymer support. This approach will be discussed in Chapter 11. 

The conversion of sugar-derived 5,6-dihydro-2-pyrones by tin(IV) chloride into 3-acyloxy and 3-acylamido-2-pyrones has appeared (Scheme 15). For example (24) gave (25). On prolonged reaction time pyrone (26) gave an almost quantitative yield of halogenated pyrone (27). 

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