Substitution of Monocarbonyl Compounds

Besides the asymmetric a-alkylation of a-amino add derivatives described above, a-substitution of other types of carbonyl compounds using cinchona PTCs have been adively developed as well. In 1990, Vandewalle and coworker used the asymmetric alkylation of isotetralone derivative 55 with 1,5-dibromopentane using 

In 2004 and 2005, Andrus and coworkers reported a new approach to the synthesis of optically active oc-alkyl-a-hydroxycarbonyl compounds by asymmetric catalytic 

In 2005 and 2006, Jorgensen and coworkers reported the development of the first catalytic asymmetric nucleophilic aromatic substitution reaction of 2-(carboethoxyjcyclopentanone (80) with highly activated aromatic electrophiles 

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