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1 substituted isoquinolines, asymmetric hydrogenations

Table 6.6 Asymmetric hydrogenations of 1 substituted isoquinolines in the presence of chloroformates and lithium salts [134]. Table 6.6 Asymmetric hydrogenations of 1 substituted isoquinolines in the presence of chloroformates and lithium salts [134].
Somewhat more effective catalysts are obtained by replacing BINAP with TolBINAP, which is 2,2 -bis(di-p-tolylphosphino)-l,l -binaphthyl.4 The presently preferred catalysts are complexes of Ru(OCOCF3)2 with (R)- or (S)-TolBINAP, obtained by treatment of Ru(OAc)2TolBINAP with 2 equiv. of trifluoroacetic acid. Such catalysts promote hydrogenation of typical enamides in 98% ee and 98% yield. This reaction can be used to provide asymmetric synthesis of isoquinoline alkaloids as well as of morphinans used as substitutes for morphine. [Pg.40]


See other pages where 1 substituted isoquinolines, asymmetric hydrogenations is mentioned: [Pg.333]    [Pg.28]    [Pg.333]    [Pg.29]    [Pg.195]    [Pg.212]    [Pg.144]    [Pg.383]    [Pg.28]    [Pg.188]    [Pg.420]    [Pg.38]    [Pg.98]   
See also in sourсe #XX -- [ Pg.196 ]




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