5-substituted aminomethyl-2 1// -pyridones

Table 3 Highly substituted 2-pyridones were aminomethylated by utilizing a microwave-assisted Mannich reaction...

Aminomethylation is possible in hydroxypyridine (V-oxides thus, for example, 9.105 is substituted at the 2- and 6-positions (74BAU2023). 3-Hydroxypyridine A-oxide itself is aminomethylated at the 2-position. 2,6-Disubstituted 3-hydroxypyridine (V-oxides react at the 4-position (72JOU416). Hydroxy-2-pyridones 9.106 and 9.107 are substituted at the 6-position (7IBAU2222). 

Several types of HA-simplffied analogs have been designed and synthesized (Figure 4-4). All of them possess the supposed pharmacophore moiety of HA. 5-Substimted aminomethyl-2(lH)-pyridones 5-substituted amino-... 

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