Subcutaneous calcinosis

Subcutaneous calcinosis occurred in two patients with renal failure who developed erythematous nodules with calcium deposition in the dermis and hypodermis [113 ], a between-the-eyes reaction of type la [114 ]. 

Two renal transplant recipients developed calcinosis cutis (tender erythematous subcutaneous nodules with induration, ulceration, and necrosis), confirmed by bone scan and biopsies, at the site of subcutaneous administration of nadroparin (72). Both had secondary hyperparathyroidism and a raised calcium-phosphate product at the time of administration. The authors suggested that the high concentration of calcium in nadroparin (220 mmol/1) had been an important factor, since in the same patients subcutaneous injections of nicomorphine or dalteparin did not cause subcutaneous nodules. Three more cases were found after retrospective examination of all 51 adult patients who underwent a renal transplantation in the same hospital during 7 months, and there were no other cases of calcinosis cutis at the injection sites of low molecular weight heparins after nadroparin was replaced by dalteparin. 

Calcinosis, subcutaneous Calcium-containing heparins [29] Histology... 

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