Subcellular Mechanisms Integration

It has been suggested that Pb causes a decrease in cholinergic functioning, which causes a corresponding increase in 

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In summary, while the relatively simple continuum models may provide a good explanation of the overall mechanical characteristics of living cells, a fuller description of subcellular deformations and interactions within the cell requires more complex microstructure-based models. In spite of many foreseen challenges, integration of continuum and micro-structural approaches into a hybrid method would allow the development of comprehensive mechanical models not only for the whole cell but also for the subcellular regions and intracellular components. Finally, it is important to point out that proper choice of theoretical models to interpret the experimental data is crucial as it can strongly affect and influence the derived cell mechanical properties. This of course requires the researcher to be fully aware of the limitations of theoretical models. 

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