Study of DNA Using Inorganic Agents

Information on the three-dimensional structure of RNA can be obtained by tethering cleavage agents to known positions and then by studying the fragments produced by the cleavage reactions. This has been used to study Escherichia coli ribosomal 

FIGURE 16-21 Gold Antiarthritic Drugs, (a) Sodium aurothioraalate. (b) Aurothioglucose. (c) Auranofin. 

Jakusch, and T. Kiss, Inorg. Chem., 2000,39,4409, and references therein. M. Uckun, Y. Dong, and P. Gosh, U.S. Patent 6,245,808, 2002. 

FIGURE 16-22 (Dipicolinato)oxovanadate(V) and Anticancer V(IV) Compounds. R-R are H, alkyl, alkoxy, halogenated alkyl, alkanoyloxy, or NO2 R -R are H, halogen, or Cj-Cg alkyl and X, X, Y, and Y are mono- or bidentate ligands. 

FIGURE 16-23 DNA Polymerase Transition State. (Redrawn from T. A. Steitz and S. A. Steitz, Proc. Natl. Acad. Sci. U.S.A., 1993, 

---