Studies on Some Reactive Intermediates and Mechanisms of Radical Reactions

Studies on Some Reactive Intermediates and Mechanisms of Radical Reactions 

The reactions were studied by on-line coupling of a microreactor system to APCI-MS and ESI-MS. The transient radical cations were detected and characterized by ESI-MS/MS. 

Through this analysis, reliable characterization of the reaction intermediates was accomplished by ESI-MS and ESI-MS/MS experiments, confirming the assumption that the fiuorination of multiply phenyl-substituted olefins follows a SET mechanism. 

The fundamental understanding of the ES ionization mechanism and the CID fragmentation behavior of ions with open and closed shells sets the stage for the analysis of solution-phase reaction mixtures. The presented examples clearly dem- 

However, reaction mechanism studies based on ESI-MS and MS require appropriate control experiments to clarify the origins and identities of detected species unambiguously as real transient intermediates of a reaction path under consideration. It is of special importance that these control experiments be carefully chosen and properly conducted to reliably exclude the formation of artefact ions by ESI, which can dramatically mislead the interpretations. 

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