Studies on Potassium Channels in Isolated Ventricular Myocytes

Studies on Potassium Channels in Isolated Ventricular Myocytes 

Patch-clamp techniques using isolated ventricular myocytes may be used measure potassium channel function to clarify the mechanisms underlying the development of torsade de pointes ventricular arrhythmias (Salata et al. 1995 Drolet et al. 1999 Kalifa et al. 1999). 

Carlsson et al. (1997) performed voltage clamp studies in isolated ventricular myocytes from rabbits. 

Carlsson L, Amis GJ, Andersson B et al. (1997) Electro-physiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro Implications for proarrhythmic potential J Pharmacol Exp Ther 282 220-227 

Drolet B, Vincent F, Rail J et al. (1999) Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current. J Pharmacol Exp Ther 288 1261-1268 

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