Stuart-Briegleb model

A recent example of a chemical study showing how strain effects could be important in an enzymatic reaction, dealt with the hydrolysis of benzaldehyde di-t-butyl acetal [18] (Anderson and Fife, 1971b). As shown by a Stuart-Briegleb model, substantial ground-state strain is present which would be partially relieved in the... 

The sulfur-bridged species 2.411c and 2.412c may formally be considered as being 18 jr-electron macrocycles. However, it was rationalized via Stuart-Briegleb model analysis that the triepoxy macrocycle 2.412c could adopt a planar conformation, whereas the thiophene-containing systems could not. Thus it was expected that the former (only) would display characteristics consistent with aromaticity. To... 

Estimated from Stuart-Briegleb ball models. 

However, Stuart-Briegleb molecular models show that ring closure in this position is subject to strong steric hindrance, whereas ring closure in position 3 is unhindered. 

Atomic Models According to Stuart and Briegleb. Arthur S. LaPine, Chicago. 

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