Strychnos ignatii

Bisset NG, Walker MD. Alkaloids from the stem bark of Strychnos ignatii. Phytochemistry 1974 13 525-526. 

Fig. 61. Strychnos ignatii Berg. From Flora of Malaya. Kep FRI No 15383. 7/21/1970. Field collector T.C. Whitmore. Geographical localization National Park, Pahang, Ulu Tembeling. Ridge northwest of Tg Bunhkal in low dense forest.

Strychnos lucida and Strychnos ignatii Berg, have been investigated for their alkaloid contents. Alkaloids isolated from the leaves of S. lucida include strychnine, brucine, pseudobrucine, normacusine B, /3-colubrine, pseudostrychnine, and brucine A-oxide. The alkaloids in the branches (without leaves) are the same as in the leaves except for the absence of pseudostrychnine and the addition of diaboline. In the root bark of this... 

Strychnine.—This alkaloid, with a chemical formula of C21H22N2-O2, occurs in the seeds of Strychnos nux vomica, Strychnos Ignatii and other species of Strychnos. When sections of strychnine con-DigitizBd by Microsoft S... 

Ignatia N.F. Seeds Strychnos Ignatii Philippine Islands... 

Aspidosperma peroba) Pleiocarpa tubicina (= Pleiocarpa pycnantha var. tubicina) Strychnos amazonica Strychnos decussata Strychnos ignatii Strychnos toxifera Strychnos usambarensis... 

In 1818 strychnine (1), which in larger amounts occurs in the poison nut Strychnos nux vomica L.) and the St. Ignatius bean (Strychnos ignatii Bergius), was isolated by Pelletier and Caventou [3] and was one of the first alkaloids obtained in pure form. Tbe structure determination by chemical degradation of the natural product, a complex structure with seven rings and six stereogenic centres, proved to be difficult and tedious. Many... 

Strychnine-Akuammicine-Condylocarpine-Ellipticine Group. Full details have been given of structural work on hunteracine chloride and of Le Goffic s synthesis " of ellipticine reviewed" in Volume 4. It has been shown that the so-called strychnicine, isolated from leaves of Strychnos ignatii and S. nux-vomica many years ago, is probably vomicine. 11-Methoxydiaboline occurs... 

Strychnine and brucine, which occur in the seeds of Strychnos nux-vomica, L. and in the beans of Strychnos ignatii, Berg., are isolated (260) by mixing the powdered seeds with slaked lime and adding sufficient water to make a paste. The paste is dried and extracted with chloroform. The alkaloids are recovered from this chloroform solution by extraction tvith dilute sulfuric acid, followed by precipitation of the bases with ammonia. Extraction of the crude alkaloid mixture with 25% alcohol dissolves the brucine, while the residue contains most of the strychnine. The crude alkaloids are purified by crystallization from alcohol. 

Strychnine was first isolated in 1818 from Strychnos ignatii by Pelletier and Caventou. Overman and colleagues did the first asymmetric total synthesis of strychnine [51]. A palladium-catalyzed carbonylative coupling of aryl iodide with an organostannanes reagent was used for the preparation of one of the intermediates (Scheme 10.6). The entire synthesis was accomplished in 20 steps and... 

Acetate (+)-29 was also the key precursor in the synthesis of (-)-strychnine.t First isolated in 1818 from Strychnos ignatii, strychnine was among the first plant alkaloids obtained in pure form. The structural elucidation was reported in 1946, and by now four total syntheses including two racemic ones have been described. The sequence described... 

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