Strychninic acid

Strychninic Acids fStrychnic Acids). Although strychnine contains two atoms of nitrogen, it behaves as a monoacidic base. Warmed with a solution of sodium ethoxide it takes up a molecule of water, forming strychninic acid, which crystallises in minute needles, m.p. 215°,... 

In the conversion of strychnine to strychninic acid, Tafel pointed out that a second acid is formed, identical with Gal and Etard s dihydrostrychnine and now known as wostrychninic acid. The preparation of... 

Strychnine A-oxide, 10 isostrychnine, 20 to 30 methylstrychnine, 100 strychnine methosulphate, 30 strychninic acid, 25 to 30 iso-strychninic acid, 30 to 35. Rats, mice, rabbits, cats, dogs and frogs were used, and the figures are comparative lethal doses for mammals. 

N-C- is termed Na). Hydrolysis of strychnine with alcoholic sodium hydroxide cleaves the lactam grouping with the formation of the amino acid, strychninic (strychnic) acid (C2oH220N(NaH) (CO2H) (2, 47, 244). Strychninic acid, which forms a nitrosamine (2), is stable to cold mineral acid but on warming a molecule of water is lost, and the lactam of strychnine is reformed (2). 

Isostrychninic acid, like strychninic acid, is an amino acid which gives a crystalline A -nitroso derivative and couples with various diazonium salts with the formation of colored azo compounds (177). Regeneration of isostrychnine results from dehydration of the acid with acetic anhydride or benzoyl chloride (241). 

Strychninic acids, 561 Strychninolic acid, 570 Strychninolone, 570 Strychninonic acid, 570 Strychnolethaline, 372 Strychnoline, 564... 

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