Strychnine toxicokinetics

Strychnine competes with the inhibitory neurotransmitter glycine producing an excitatory state characterized clinically by hyperreflexia, severe muscle spasms, and convulsions. However, the toxicokinetics after overdose have not been well described. In most severe cases of strychnine poisoning, the patient dies before reaching the hospital (Shadnia et al., 2004). 

Metabolic fate of strychnine in rats. Xenobiotica 19 171-8. Palatnick, W., Meatherall, R., Sitar, D., Tenenbein, M. (1997). Toxicokinetics of acute strychnine poisoning. J. Toxicol. Clin. Toxicol. 35 617-20. 

Wood, D., Webster, E., Martinez, D., Dargan, P., Jones, A. (2002). Case report survival after deliberate strychnine self-poisoning, with toxicokinetic data. Crit. Care 6 456-9. 

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