Strychnine is the chief alkaloid present in nux vomica

FIGURE 89 Strychnine is the chief alkaloid present in nux vomica. In cases of poisoning, it causes convulsions which are accompanied by strong contraction of the face muscles. The respiratory muscles are involved in the general paroxysm and the blood rapidly becomes deoxygenated. 

8 hours (10 ng/kg) for 5 days and then every 12 hours for an additional 2 weeks. 

Succimer (2,3-dimercaptosuccinic add, Chemet) is an orally effective chelator that is chemically similar to dimercaprol but contains two carboxylic acids that modify both the distribution and chelating spectrum of the drug. 

After its absorption in humans, succimer is biotransformed to a mixed disulhde with cysteine. 

Succimer produces a lead diuresis with a subsequent lowering of blood lead levels and attenuation of the untoward biochemical effects of lead, manifested by normalization of 5-ALA dehydrase activity. The succimer-lead chelate also is eliminated in bile the fraction eliminated undergoes enterohepatic circulation. 

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