Structures of Nucleotides and Oligonucleotides

The molecniar stmcture of DNA was unraveled in 1953 by Watson and Crick [1]. DNA is a Unear polymer of nucleotides (nt) arranged in a doubly stranded helical 

Fundamentals (tf Contemporary Mass Spectrometry, by Cbhabil Dass Copyright 2007 John Wfley Sons, Inc. 

In the double-helical structure of the DNA, the two oligonucleotide chains are complementary in their base sequences and are arranged in opposite directions.  

Solution The monoisotopic molecular mass of an oligonucleotide = 17.003 + (the sum of the monoisotopic residue masses) + 17.003 — 95.961. Therefore, the 

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