Structure of Sirtuins

The secondary structure of the proteins are shown as dark gray helices and the beta strands and coil regions are in light gray. The zinc ions are shown as spheres, (b) The NAD molecule bound to the enzyme and the acetylated peptide of p53 are shown as ball and sticks. The acetylated lysine is labeled. 

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Figure 3.7 Molecular structures of sirtuin inhibitors mentioned in the text.

Fig. 13 Structures of sirtuin activators (a) pyrroloquinoxaline 48 (b) Structure and Sirtl activation data for dihydropyridines 49-51...

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