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Structure Based DD in HtL

AlphaScreen IC50 = 0.30 pM Design based on SBDD (S)-methyl important, axial required [Pg.356]

AlphaScreen IC50 = 0.036 pM Better H-bond trajectory phys props [Pg.356]

AlphaScreen IC50 = 0.0097 pM Axial Me group boosts activity [Pg.356]

AlphaScreen IC50 = 0.021 pM Reduced lipophilicity Improved cellular potency [Pg.356]

Acylated piperidines force ( -substituents into axial confomnation [Pg.358]

See other pages where Structure Based DD in HtL is mentioned: [Pg.356]    [Pg.357]   


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