Structure-Activity Relation SAR of Bisacylhydrazines

Dinan and Hermann [6] made the following observations for a BAH pharmacophore with toxidty related features common to spedes from sensitive insed orders (mainly Lepidoptera and Coleoptera)  

Two hydrogen acceptor or polar negative atoms that are 3.5-4.0A apart. 

A bulky, conformational-determining lipophilic group located asymmetrically between the two negative centers. 

Moderately sized (about six carbons) groups on either side of the negative centers. Aryl groups are favored for both Lepidopteran and Coleopteran activity. 

A hydrogen bond-donating group located near the alternate negative center. 

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