Structurally and mechanistically diverse libraries used for chemical genetics

2 Structurally and mechanistically diverse libraries used for chemical genetics 

The total chemical space is estimated as 10 ° distinct compounds (Mwt 500 Da), although only 10 can be considered as drug-like and this set is composed of 10 different cores or scaffolds (Dean, 2007). From commercial sources, approximately 25 million compounds (ZINC database) (Irwin and Shoichet, 2005) are available although the diversity, particularly the skeletal diversity, is far behind what DOS strategy offers. On the 

A similar concept uses chemogenomic reference libraries, which results in chemogenomics/toxicogenomics fingerprints for comparative studies. 

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