Structural optimization of organic bridges on Toyonite

Effect of organic bridges on the royonite-immobilized lipase-cataiyzed resolution of ( )-4 

Practical resolution of azirine 1 by the low-temperature method combined with Toyowifc-immobilized lipase and optimized acylating 

These results indicate that the low-temperature method increases the enantioselectivity, at least above inversion temperature, and the enantioselectivity and reaction rate can be optimized by the use of Toyon/te-immobilized lipase and a suitable acylating agent. 

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