Structural Biology in a Nutshell

The latter facilitates conformational movements during catalysis (such as the induced fit , see below) thereby underlining the pronounced dynamic character of enzyme catalysis. Besides the main polyamide backbone, the only covalent bonds are -S-S- disulfide bridges. Enzymes are intrinsically unstable in solution and can be deactivated by denaturation, caused by increased temperature, extreme pH, or an unfavorable dielectric environment such as high salt concentrations. 

The types of reaction leading to an enzyme s deactivation are as follows [88]  

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