Structural and Cell Biology in Iron Metabolism

Convergence OF Structural and Cell Biology IN Iron Metabolism 

A breakfest with Dr. Daniel Yuan resulted in a collaboration on FetSp from Sacchar-omyces cerevisiae, a collaboration that was made possible by Dr. Yuan s pioneering efforts. This collaboration has included the laboratories of Drs. Ninian Blackburn, John McCracken, and Edward Solomon. Members of these labs who have participated in this collaboration are Martina Ralle, Constantino Aznar, Timothy Machonkin, Liliana Quintanar, and Amy Palmer. All members of my own lab contributed to this work, most particularly Richard Hassett, Scott Severance, and Kimberly Prohaska. Of course, little good happens in the Kosman lab without the critical assistance of Annette Romeo, and our work on FetSp and the iron—copper connection owes much to her efforts. The support for this work by the NIH (DK53820) is gratefully acknowledged. 

Abboud, S., and Haile, D. J. (2000). A novel mammalian iron-regulated protein involved in intracellular iron metabolism./. Biol. Chem. 275, 19906-9912. 

Askwith, C., Eide, D., Van Ho, A., Bernard, P. S., Li, L., Davis-Kaplan, S., Sipe, D. M., and Kaplan, J. (1994). The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell 76, 403 10. 

Askwith, C., and Kaplan, J. (1997). An oxidase-permease-based iron transport system in 

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VII. Convergence of Structural and Cell Biology in Iron Metabolism. 263... 

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