Strophanthidin cardiotonic activity

Perhaps the strongest support for the argument, that enhancement of cardiotonic activity by the carbohydrate component is a function of hydroxylation, may be gained by inspection of the potencies of the completely deoxygenated 3-tetrahydropyranyl derivatives of digitoxigenin (1) and of strophanthidin (2) (see Table I). In each case, the value ob-... 

The chemistry and antitumor and cardiotonic activity of strophanthidin derivatives has recently appeared. Lactams were prepared from cardenolldes and ammonia or amines, but they were devoid of appreciable cardiotonic activitySl,... 

The cardiac activity found for the iodoacetate (88) obtained from the strophanthidin derivative (87) was originally interpreted as a cardiotonic effect and considered to be in agreement with the suggestion that activity is dependent upon the ability of the compound to react with -SH groups. Further work on... 

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