Strobilurus tenacellus

It is interesting that a new group of fungicides based on the natural products from the fungus Strobilurus tenacellus also inhibit mitochondrial respiration at the site of complex III (bei-complex) of the respiratory chain (see Chapter 4). Recently synthesised compounds from within this class are showing interesting insecticidal effects. 

By the early 1980s, the in vitro activity of strobilurin A, the compound from Strobilurus tenacellus, and oudemansin A, from Oudemansiella mucida, had been completely characterised13 (Figure 4.23) and the mode of action was known to be the inhibition of electron transfer in complex... 

T. Anke, F. Oberwinkler, W. Steglich and G. Schramm, The Strobilurins-new antifungal antibiotics from the basidiomycete Strobilurus tenacellus, J. Antibiot., 1997, 30, 806-810. 

S. A from cultures of the pine-cone fungus Strobilurus tenacellus is identical to mucidin originally errone-... 

S. A"-- S. B 258.32 oil 52110-55-1 Strobilurus tenacellus, Agaricus, Bolinea, Cyphellopsis, Favolaschia, Hydropus, Mycena (16 species ), Oudemansiella, Pterula, Strobilurus, Xerula... 

C17H19CIO4 322.79 rhomb, cryst. 65105-52-4 Strobilurus tenacellus, Bolinea, Mycena,... 

In a Petri-dish assay, Strobilurus tenacellus forms a halo. 

The cytochrome be, complex of Saccharomyces cerevisiae. A few amino acids (shown in blue) In Strobilurus tenacellus are responsible for Its natural resistance to strobilurins and oudemansins (binding pockets Qo and Qi ochre, b and b haem pink, FeS cluster yellow and brown). 

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