Striatal kainic acid lesion

Coyle JT, Schwarcz R (1976) Lesion of striatal neurones with kainic acid provides a model for Huntington s chorea. Nature 263 244-246. 

KorfJ and Venema K (1983) Ammo acids in the substantia nigra in rats with striatal lesions produced by kainic acid. / Neurochem 40, 1171-1173... 

Co-injection of glutamic acid with kainic acid, neither of which are neurotoxic in the decorticate striatum, partially restores kainate s neurotoxicity in this region (Biziere and Coyle, 1979). The essential role of these cortical afferents in the neurotoxic action of kainate has been conclusively established in tissue culture. Explants of striatum cultured alone are insensitive to the neurotoxic effects of kainic acid however, when the striatum is co-cultured with cortical explants resulting in the development of cortical innervation of the striatum, kainate added to the culture medium is effective in lesioning the striatal neurons (Pannula, 1980 Whetsell et al, 1979). 

Meibach, R. C., Brown, L., and Brooks, F. H., 1978, Histofluorescence of kainic acid-induced striatal lesions, Brain Res. 148 219-223. 

ScHWARCz, R., and Coyle, J. T., 1977a, Striatal lesions with kainic acid neurochemical characteristics. Brain Res. 127235-249. 

Oral administration of 1 % creatine to male Sprague-Dawley rats significantly attenuated striatal excitotoxic lesions produced by N-methyl-D-aspartate, but had no effect on lesions produced by a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid or kainic acid (Malcon et al. 2000). 

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