Stress Succinic dehydrogenase

The exact mechanism of toxicity is not clear. In vitro studies suggested that incubation of dichlone with normal human erythrocytes induced rapid loss of intracellular potassium, increased the osmotic fragility, and inhibited the Na, K + -ATPase. Dietary dichlone exposure caused inhibition of glycolysis in rat liver. Dichlone can inhibit pyruvate and succinate dehydrogenases. Dichlone was also reported to cause oxidative stress and swelling of mitochondria. 

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