Streptomyces toyocaensis

A41030 complex Streptomyces toyocaensis NRRL 15156 1982 Lilly... 

Solenberg PJ, Matsushima P, Stack DR et al (1997) Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis. Chem Biol 4 195-202... 

Toyocamycin (314) is another adenosine derivative produced by Streptomyces toyocaensis [18]. This compound selectively inhibits the ribosomal RNA synthesis in fibroblasts. The synthesis of adenovirus-specific mRNA is also inhibited by 314 [18]. 

C7H9NO2, Mr 139.15, amorphous powder, [a]u-454° (H2O). Synthetic racemate, mp. 196-197 °C antibiotic from Streptomyces toyocaensis, G. inhibits the enzyme GABA aminotransferase by formation of a Schiff s base and subsequent (irreversible) aromatiza-tion with formation of a m-anthranilic acid derivative. For racemic synthesis, see Lit, asymmetric or regio-selective syntheses, see... 

Toyocamydn Streptomyces toyocaensis, S rimosus 4-Amino-5-cyano- 7-pyrrolopyriniidine Ribose Adenosine... 

Toyocamydn 4-amino-5-cyano-7-(D-ribofurano-syl)-pyrrolo-(23-d)-pyrimidine 6-amino-7-cyano-9-P-D-ribofuranosyl-7-deazapurine, a 7-deazaadenine antibiotic from Streptomyces toyocaensis and S. rimosus. M.p. 243 C. Biosynthesis is analogous to that of Tii-bericidin (see), i.e. the carbon atoms of the pyrrole ring are derived from 5-phosphoribosyl 1-pyrophosphate. T. is particularly active against Candida albicans, Saccharomyces cerevisiae and Mycobacterium tuberculosis. 

Nucleoside antibiotic. Isol. from Strepto-myces gougerotii, Streptomyces toyocaensis, Streptomyces quingfengmy-ceticus, Streptomyces puniceus doliceus and Streptomyces... 

C12H13N5O4 291.266 Isol. from Streptomyces toyocaensis and Streptomyces fungicidicus. Active against gram-positive organisms shows some exp. antineoplastic activity. Needles or prisms + IH2O. 

Kawanami, J. Lipids of Streptomyces toyocaensis. On the Structure of Siolipin. Chem. Phys. Lipids 7, 159 (1971). 

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