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The two geminal methyl groups at C-3 appear as an important structural requirement for antitumor activity in the series. Indeed, 3-hydroxymethylacronycine (321. obtained by addition of acronycine to a metabolizing culture of Streptomyces spectabilicus, was devoid of antitumor activity when tested in mice implanted with X-5563 plasma cell myeloma or C-1498 myelogenous leukemia (36). More recently, Reisch et al. prepared... [Pg.796]

See other pages where Streptomyces spectabilicus is mentioned: [Pg.354] [Pg.381] [Pg.354] [Pg.381]

See also in sourсe #XX -- [ Pg.354 , Pg.381 , Pg.382 ]

See also in sourсe #XX -- [ Pg.20 , Pg.796 ]

See also in sourсe #XX -- [ Pg.20 , Pg.796 ]