Streptomyces indolizomycin

The isolation, structural elucidation, and biological activity of the extraordinary metabolite indolizomycin (63) were described in the earlier review on simple indolizidine and quinolizidine alkaloids in Volume 28 of this series (7). The compound was obtained from a mutant Streptomyces strain bioengineered by protoplast fusion of two strains that do not normally produce antibiotics 54). It was reported to be exceedingly unstable, undergoing decomposition within a few hours under neutral conditions at room temperature. 

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