Streptomyces griseoaurantiacus

Bicyclic nucleoside derivatives formed biosyntheti-cally by linkage of oxaloacetate to adenosine. The three components (G. A to C) are produced by Streptomyces griseoaurantiacus. They are competitive inhibitors of eyclic AMP phosphodiesterase (Kj=0.16 mM). G. A stimulates glycogen mobilisation in the liver, in the mouse this leads to a higher blood glucose level. 

C,4H,3N507 363.286 From Streptomyces griseoaurantiacus. Inhibits cyclic-AMP phosphodiesterase. Cryst. Sol. H2O, MeOH. 

---