Strategy to Solve Structural Problems

Following the strategy of spectral analysis at this stage, an NMR investigation could be based on a multiple parameter approach, or may be restricted to the evaluation of one or two NMR parameters only. It is this former multiple parameter approach, together with information obtained from other spectroscopic techniques (MS, IR, UV,. ..), which has made high resolution NMR today s most popular tool for structure elucidation. 

The steps in a typical multiple parameter NMR analysis (see below), may be 

Spin-spin connectivities (homo-/heteronuclear) based on scalar coupling over one or 

spin connectivities based on dynamic exchange including the parameters necessary to quantify these processes (k, AG , AH , AS ). 

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