Stimulation of Gelation by Perturbations Other Than Temperature

Stimulation of Gelation by Perturbations Other Than Temperature 

Enzymatic In situ Formation of Celators and Cels - Potential Biological Applications 

For example, while Fmoc-phenylalanine produced a stable gel, Fmoc-glycine did not under the same conditions. The relative amount of product produced (54% for Fmoc-phenylalanine vs 8% for Fmoc-glycine) is consistent with the decreased driving force for self-assembly of the more soluble derivative. A notable advantage of this approach is the lack of side products (with the exception of water) of the reaction. 

Any stimulus-responsive gel can serve potentially as a simple test to detect the presence of a selected perturbation. The outcome of such a test is easily monitored 

Fmoc-amino acids (gray) are enzymaticaiiy coupied to dipeptides (biack) by a protease to form Fmoc-tripeptides that seif-assembie to higher-order aggregates driven by 7t—w interactions between fiuorenyi groups. represents the equiiibrium constant for 

---

Stimulation of Gelation by Perturbations Other Than Temperature I 33... 

---