Stimulation of Chemosensory Discharge by Iron Chelation

Chelation of Fe is expected to decrease OH radical (ROS) by inhibiting the Fenton reaction (14,15). This decrease in ROS production is expected to stimulate the chemosensory discharge (16). Also, chelation of iron is expected to stabilize the cellular HIF-1k, thereby mimicking hypoxia (17). By both counts, chelation of Fe is to mimic hypoxia. 

CPX also suppressed the outward whole-cell K currents of rat glomus cells dining normoxia (Fig. 5), mimicking the hypoxic effects (not shown). A similar result has been found in the PC-12 cells (20). In the PC-12 cells, the suppresssed K  

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