Stille coupling aryl chloride catalyst development

As mentioned in previous sections, aryl chlorides are attractive for coupling reactions since they are typically less expensive than aryl bromides or iodides. To address this issue, Buchwald developed a simple catalyst system consisting of a ferrocene-based ligand and PdCOAc) as the metal source (Scheme 4.179 and Example 4.30) [288]. While only a single aryl chloride was reported, it still demonstrated that aryl chlorides could be used in the... 

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