Stetter, Hermann

Sauer. John C., 3 Schaefer. John P 15 Schorc. Neil E.. 40 Schulenberg, J. W., 14 Schweizer, Edward E., 13 Scott. William J.. 50 Scribner. R. M.. 21 Sccbergcr, Peter H., 68 Semmelhack. Martin F 19 Sengupta, Saumitra, 41 Sethna. Suresh. 7 Shapiro. Robert H.. 23 Sharts, Clay M.. 12. 21 Sheehan, John C.. 9 Sheldon. Roger A.. 19 Sheppard. W. A.. 21 Shibasaki. Masakatsu. 70 Shirley, David A.. 8 Shriner, Ralph L.. I Simmons. Howard E 20 Simonoff, Robert. 7 Slowinski. Franck. 68 Smith, Lee Irvin. I Smith. Peter A. S., 3, 11 Smithers. Roger. 37 Snow. Sheri L 66 Spielman. M. A.. 3 Spoeni, Paul E., 5 Stacey, F. W 13 Stadler. Alexander. 63 Stanforth. Stephen P.. 49. 56 Stetter. Hermann. 40 Struve, W. S., 1 Suter. C. M 3 Swamer. Frederic W.. 8 Swem. Daniel. 7... 

During the early 1970s, Hermann Stetter investigated the reaction of the acylan-ion equivalent 26 with Michael acceptors such as 27 (Scheme 9.7) [37]. Since that... 

Prof. Dr. Hermann Stetter Institut fur Organische Chemie der TH Aachen... 

The Catalyzed Nucleophilic Addition of Aldehydes to Electrophilic Double Bonds Hermann Stetter and Heinrich Kuhlmann... 

Dihydrojasmone is also much valued as a scented compound because of its floral and fruity character. A convenient synthetic route is provided by the Stetter reaction (a reaction of aldehydes with Michael acceptors in the presence of thiazohum salts, developed by Hermann Stetter (1917-1993)) of methyl vinyl ketone and heptanal [90], followed by an intramolecular aldol condensation. 

In a series of publications beginning in 1973, Hermann Stetter and coworkers reported that activated olefins could intercept the putative acylanion intermediate of the benzoin reaction. Typical catalysts for the benzoin reaction, sodium cyanide and thiazolylidine carbenes, were found to perform well in this new reaction. Stetter also established that the success of the reaction is due to the reversible nature of the benzoin condensation relative to the irreversible formation of 1,4-dicarbonyl products. As a consequence, benzoins or aldehydes can be used interchangeably as reactants. The reaction has proven to be a highly efficient method for the synthesis of 1,4-dicarbonyl compounds and 4-oxonitriles. A resurgence of interest in acyl anion chemistry has resulted in many new discoveries, including alternative acyl donors, as well as catalysts capable of highly enantioselective intra- and intermolecular Stetter reactions. ... 

Helpful discussions with Frank Stetter, Stefanie Ktysiak, Michael Schlierf, and Hermann Caub are gratefully acknowledged. We thank the Deutsche Fotschungsgemeinschaft (Hu 997/4-2), Nanosjrstems Initiative Munich (NIM), and BMW AG for financial support. B.N.B. is supported by the NIM Graduate School. 

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