Sterol sensor

In addition to PXR and CAR, several other nuclear receptors, such as vitamin D receptor (VDR), hepatocyte nuclear factor 4a (HNF4a), peroxisome proliferator-activated receptors (PPARs), and farnesoid X receptor (FXR), have also been implicated in the regulation of xenobiotic enzymes and transporters [9-12], More recently, results from our lab have shown that the liver X receptor (LXR), a previously known sterol sensor, can also regulate the expression of phase II SULTs, such as the bile acid detoxifying hydroxysteroid sulfotransferase Sult2a9/2al [13] and the estrogen sulfotransferase (Est/Sultlel) [14],... 

Goldstein, J. L., DeBose-Boyd, R. A., Brown, M. S. (2006). Protein sensors for membrane sterols. Cell, 124, 35-46. 

Goldstein JL, DeBose-Boyd RA, Brown MS (2006) Protein sensors for membrane sterols. Cell 124 35 6 Gombos I, Bacso Z, Detre C, et al. (2004) Cholesterol sensitivity of detergent resistance a rapid flow cy-... 

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