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Sterol cyclases, evolution

BUNTEL GRIFFIN Evolution of Sterol and Triterpene Cyclases... [Pg.45]

Recent mechanism studies involving incubations with stable isotopes (66,69,70) and studies by us on conformiational analysis (38-42), distribution (7), structure-function/metabolism relationships (54, 55) and mechanistic enzymology of sterol transformation (12,56), negate the otherwise attractive explanation hypothesized by Ourisson et al, (9,10) for evolution of the sterol pathway beginning with the cycloartenol-based pathway. The new data indicate that the lanosterol-based pathway may have evolved before cycloartenol-based pathway, the squalene-oxide cyclase and... [Pg.76]

See other pages where Sterol cyclases, evolution is mentioned: [Pg.472]    [Pg.47]    [Pg.65]    [Pg.65]    [Pg.65]    [Pg.70]    [Pg.87]    [Pg.46]    [Pg.40]    [Pg.44]    [Pg.64]    [Pg.72]    [Pg.72]    [Pg.84]   
See also in sourсe #XX -- [ Pg.44 , Pg.45 , Pg.46 , Pg.47 , Pg.48 , Pg.49 , Pg.50 , Pg.51 , Pg.52 ]



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