Sterilization radical formation during

A detailed mechanistic elucidation was performed to decipher HAS depletion during gamma-irradiation of PP films at a sterilization dose of 2.5 Mrad and 35 °C [226,227]. It was found that 28, R = H, 28, R = CH3, and 34 lose the ester group. The piperidine nucleus was not degraded in this phase [226], The primary attack is probably on the methylene group in the a-position to the carbonyl. Formation of a free-radical fragment 147 is followed by further scission during... 

---