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These extensive SAR studies have shown that the rigid biaryl/nine-membered lactam structure of rhazinilam adopting a boat-chair conformation is an essential feature for its antimitotic properties. Moreover, the absolute aR configuration of the biaryl axis is, as in the allocolchicine and stegane series, absolutely required for biological... [Pg.410]

See other pages where Steganes absolute configuration is mentioned: [Pg.360] [Pg.388] [Pg.400] [Pg.360] [Pg.388] [Pg.400]

See also in sourсe #XX -- [ Pg.360 ]

See also in sourсe #XX -- [ Pg.360 ]

See also in sourсe #XX -- [ Pg.29 , Pg.360 ]