Stearoyl-lysine

Au photoelectrons are spin polarized due to the high spin-orbit coupling of the metal. Therefore, an alternative mechanism for the transmission asymmetry obseved in [36] could be based on changes in the photoelectron spin angular momentum. We do not attribute the yield asymmetry to spin polarization because the stearoyl-lysine monolayers in [36] contain only low atomic number atoms that do not scatter spin. 

Scheme 8.3 Formulae Cig-Lys-N -stearoyl-lysine, Cig-Lys-TE-N -stearoyl-lysine-thioethyl eS ter, Cig-Lys-NCA-N -stearoyl-lysine-N -carboxyanhydride, Cig-Glu-O -stearyl-glutamic acid, Cig-Glu-NCA-0> -stearyl-...

The observation that copper supplementation modulates the formation of arachidonic acid by regulating A -desaturase activity, which converts diho-mo-y-linolenic acid to arachidonic acid, has led to the suggestion that combinations of linoleic, y-linolenic or dibromo-y-linolenic acid with assimilable copper complexes might be useful in the treatment of inflammatory disorders, cardiovascular and thrombotic disorders, menstrual cycle disorders, diabetes, endometriosis, nutritional deficiencies and malignancies [255]. Modulation of stearoyl CoA A -desaturase activity by Cu(II)(tyrosinate)2, Cu(II)(lysinate)2, and Cu(II)(histidinate)2 [599] may also have a bearing on these uses of copper complexes. 

These observations are also consistent with copper complex modulation of A terminal desaturase activity [702]. A purified chicken liver microsomal preparation of stearoyl-CoA A -desaturase was inhibited with Cu(IIXtyrosi-nate)j, Cu(II)(lysinate)2 and Cu(II)(histidinate)2. These chelates lowered the steady-state level of ferrocytochrome only 20% and only partially inhibited the NADH-ferricyanide reductase activity, indicating that the terminal desaturation step was being inhibited. Since oxygen is known to be involved in this desaturation and that there is an initial reduction of the desaturase iron, it is plausible that these chelates are decreasing desaturase activity by acting as superoxide scavengers [702]. 

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