Steady state NOE in paramagnetic compounds

200 s-1. The dependence on xr under the same conditions is shown at 800 MHz (Fig. 7.2B). From Fig. 7.2A it appears that at low cor values (fast motion limit) and R[m = 0 the maximal homonuclear NOE is 0.5, whereas at large values of cut (slow motion limit) the maximal NOE is —1. Of course, these are limiting values in the absence of R[m (and P/(other)) the hyperfine coupled relaxation decreases the above absolute values, but leaves the dependence unaltered. The NOE is larger at larger magnetic fields and/or when rotation is slowed down (Fig. 7.2B). It is important to note that, for very long xr values, NOE values close to —1 could 

In Table 7.2 some significant examples of the NOEs observed in paramagnetic 

Some examples of NOE detected on paramagnetically shifted signals in metalloproteins [12] 

The counterpart of this simplification is that the NOE is dramatically reduced by the short pi values. 

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