Status epilepticus lidocaine

Although other drugs such as lidocaine have been recommended for the treatment of generalized tonic-clonic status epilepticus, general anesthesia is usually necessary in highly resistant cases. 

Aggarwal P, Wall JP. Lidocaine in refractory status epilepticus A forgotten drug in the emergency department. Am J Emerg Med 1993 2 243-244. 

An 8-month-old boy who had been given oral modifled-release theophylline and additional aminophylline suppositories developed convulsive status epilepticus [96 ]. A combination of diazepam, lidocaine, and thiopental was required to stop the convulsion. A pharmacokinetic study showed that the use of the mod-ified-release formula would have given a plasma concentration of no more than 15 mg/ 1, but that the addition of aminophylline would have increased it to over 20 mg/1. 

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