Statins Tacrolimus

STATINS TACROLIMUS Single case report of rhabdomyolysis when was simvastatin added to tacrolimus Uncertain at present Monitor LFTs and CK closely warn patients to report any features of rhabdomyolysis... 

In 25 renal transplant recipients who took tacrolimus, of whom nine also took a statin, tacrolimus significantly increased plasma triglyceride concentrations, which the authors attributed to reduced lipoprotein lipase activity [82 ]. 

CYP3A4 Alfentanil Alprazolam Astern izole Carbamazepine Cisapride Cyclosporine Diltiazem Erythromycin Felodipine Fluconazole Itraconazole Ketoconazole Lidocaine Lova statin Midazolam Nifedipine Quinidine Simvastatin Tacrolimus Terfenadine Verapamil... 

Drug interactions mediated by CYP3A inhibition can be severe e.g., nephrotoxicity induced by cyclosporine and tacrolimus and rhabdomyolysis resulting from increased levels of statins). Whenever an inhibitor of the CYP3A isoforms is administered, the clinician must be cognizant of the potential for serious interactions with drugs metabolized by CYP3A. 

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