Statin mitochondrial activity

Nadanadva, S. etal. (2007) Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration. Toxicology and Applied Pharmacology,... 

In four patients with muscle symptoms while taking statins, creatine kinase activity was normal, but they were subsequently able to distinguish from their symptoms whether they were taking drug or placebo muscle biopsies showed evidence of mitochondrial dysfunction (45). 

CafforioP, Dammacco F,Gernone A, SilvestrisF. Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis 2005 26 883-891. 

Rab [87], and Rap [84], For example, statins induce apoptosis at concentrations that suppress the prenylation of Rap la (a 21 kDa GTPase) [84], and Itagaki et al. have shown that this process is accompanied by the redistribution of small G proteins in myoblasts [88], It remains unclear, however, whether the altered prenylation of small G-proteins is necessary and sufficient to produce myopathy in vivo, or whether myocyte apoptosis is first activated by disrupted Ca2+ homeostasis following mitochondrial injury. 

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