Stapled peptide modulation

Stapled Peptide Modulation of Drug Target Space... 

Stapled peptides are designed to increase the a-helix content in solution and are expected to produce higher affinity ligands compared to the natural peptide modulators. The following examples demonstrate this correlation, although it should be noted that peptide stapling does not always lead to an increase in affinity. 

For the past decade, stapled peptides have emerged as a novel class of dmgs (see ref. 19-24,27-29 and 62 for reviews) for the modulation a plethora of intracellular targets i.e. 

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