Stapled Peptide Affinity and a-Helix Content Correlation

43 Stapled Peptide Affinity and a-Helix Content Correlation 

Stapled peptides are designed to increase the a-helix content in solution and are expected to produce higher affinity ligands compared to the natural peptide modulators. The following examples demonstrate this correlation, although it should be noted that peptide stapling does not always lead to an increase in affinity. 

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