Standard operating procedures troubleshooting

This chapter describes how to be more successful in HPLC operation by summarizing a series of standard operating procedures representing the best practices of experienced HPLC analysts. It offers some brief guidelines on maintenance/troubleshooting and on means of enhancing HPLC assay precision. 

Use and refine the standard operating procedures (SOPs) for operation, maintenance, sanitization and troubleshooting. 

Any modifications that affect standard operating procedures, drawings, plant troubleshooting, plant numbering, equipment schedules and maintenance need to be considered by the commissioning team. If they have not been covered in the contract, they are the responsibility of the owner. If serious changes have occurred a Hazop or design review study is essential and, if necessary, expert advice should be taken. 

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